3) Immune Checkpoint Inhibitors for Gastrointestinal Tract Cancers
نویسندگان
چکیده
منابع مشابه
Current Status of Immune Checkpoint Inhibitors in Gastrointestinal Cancers
The expansion of our understanding of tumor immunity and the recent success of new cancer immunotherapy has reignited the hope that we can treat cancer effectively with immunotherapeutic approaches. Immune checkpoint inhibitors have shown significant efficacy in the treatment of some solid and hematologic malignancies. Encouraged by recent success in some other types of malignancies, many clini...
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Immune checkpoint inhibitors represent revolutionary anti-cancer agents, being rapidly approved in different malignancies and settings. Gastrointestinal (GI) cancers represent a wide variety of tumors with specific characteristics and different responses to various therapeutic alternatives; while some are chemo-sensitive others are chemo-resistant and only respond to more aggressive cytotoxic r...
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In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy targeting the immune checkpoint receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death 1 (PD-1), and programmed cell-death ligand 1 ...
متن کاملCheckpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract
Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has led to a new class of immune-related adverse events. In many respects, these ...
متن کاملSurgery for Cancers of the Gastrointestinal Tract.
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2019
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.108.130b